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04/Mar/2024

In the never-ending quest for more effective mental health treatments, a centuries-old compound is re-emerging with potential to revolutionize the field. Psilocybin—known for its presence in “magic mushrooms”—is at the heart of a new wave of psychotherapy, proving to be an intriguing addition to the toolkit of psychiatrists and mental health professionals. This blog post will explore the advancements in assisted psilocybin psychotherapy, shedding light on its potential, current state, and future trajectory.

Understanding Psilocybin Psychotherapy

Unlocking the Substance

Initially introduced to the masses by indigenous cultures, psilocybin is a naturally occurring compound found in certain mushrooms. It became widely known in the West during the counterculture movement of the 1960s, only to be banned in many countries following stricter categorization of substances. Despite this, research persisted underground and in more permissive regions.

Delving into the Psychedelic Experience

When correctly administered in a controlled environment, psilocybin produces powerful psychological effects, including a profoundly altered state of consciousness. This experience, often described as “psychedelic,” can involve euphoria, introspective insights, and a sense of interconnectedness with the universe. In the context of therapy, this altered state is approached with intention, guiding patients through a process of self-reflection and emotional healing.

Benefits of Assisted Psilocybin Therapy

Mental Health Improvements

Research indicates that psilocybin therapy has the potential to significantly alleviate symptoms in various mental health conditions, such as depression, anxiety, and PTSD. The therapy’s effects are reported to be enduring, with some studies showcasing a single dose’s ability to induce a lasting positive shift in mood and outlook.

Treatment-Resistant Conditions

One of the most promising aspects of psilocybin therapy is its ability to aid individuals who are resistant to traditional treatment. In the realm of depression, where conventional approaches can fail a significant portion of patients, psilocybin might provide a much-needed alternative path toward healing.

Holistic Healing Approach

Assisted psilocybin therapy is more than just a psychological experience; it’s frequently described as a spiritually significant event. Its holistic approach addresses the interconnected nature of mental, emotional, and sometimes even physical well-being, leading to a more comprehensive healing process.

Current Research and Studies

Groundbreaking Discoveries

Recent studies on psilocybin therapy have provided compelling evidence of its effectiveness. For instance, a landmark study at Imperial College London revealed that patients with treatment-resistant depression experienced substantial reductions in depressive symptoms after two doses of psilocybin. Other research explores its potential for smoking cessation and even end-of-life anxiety in terminally ill patients.

Clinical Trials and Methodologies

To legitimize its medical application, psilocybin therapy is undergoing rigorous clinical trials. These trials employ a blend of traditional psychological support alongside carefully structured doses of psilocybin, ensuring the patients’ safety and maximizing the therapeutic experience.

Challenges and Considerations

Legal and Ethical Hurdles

Despite growing evidence of its benefits, psilocybin’s societal and legal status presents significant barriers. Its current classification as a Schedule I substance in the United States, for example, places tight restrictions on its use and research. There are also ethical considerations surrounding its use in therapy and accessibility to patients in need.

Integration into Mainstream Healthcare

For psilocybin therapy to reach its full potential, it must find acceptance within mainstream healthcare systems. This involves not only changing legal frameworks but also navigating the cautious medical landscape wary of its past associations with recreational use.

Future Outlook

Potential Impact on Mental Health Treatment

Should psilocybin therapy continue to demonstrate positive outcomes, it has the potential to reshape mental health treatment paradigms. Its possible use alongside, or in place of, traditional psychiatric medications is a promising avenue, offering a different approach for people who do not respond to conventional treatments.

Opportunities for Further Research and Development

The future of psilocybin therapy lies in extensive further research, exploring dosing regimens, the optimal therapeutic settings, and the full scope of its potential applications. Additionally, there’s room for the development of supportive technologies and treatment protocols addressing patients’ post-therapy integration and aftercare.

Conclusion

The recent advancements in assisted psilocybin psychotherapy mark a pivotal moment in the evolution of mental health care. While it faces significant hurdles, the accumulating evidence of its therapeutic capabilities, combined with the growing cultural openness to alternative healing modalities, suggests a bright future. The potential to uplift countless individuals from the trenches of mental health struggles underscores the importance of continuing the conversation and research around this potentially game-changing form of therapy. With the right support and approach, psilocybin therapy could stand as a beacon of hope for those in need of relief from the burdens of the mind.

For ongoing clinical trials and an in-depth look at psilocybin assisted therapy check out the work being done at Compass Pathways

Here are a few centres offering psilocybin assisted therapy:

Empire Psychotherapy 
Numinus
Dr. Erica Zelfand N.D.

Check out my article on Psilocybin and the Default Mode Network Click Here


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04/Feb/2023

Over the past few years, there has been a lot of buzz around psilocybin, a psychedelic compound found in some types of mushrooms. Although the use of psychedelic mushrooms may be most often associated with recreational use, researchers are now starting to see the potential for therapeutic benefits. New studies have revealed that psilocybin can have a profound effect on our brains by altering the activity of something called the “default mode network.” Let’s take a closer look at how this works.

What Is The Default Mode Network?

The default mode network (DMN) is a set of brain regions that are active when we’re not actively engaged in any task or conversation. It’s responsible for helping us think about ourselves and our place in the world, which is why it’s sometimes referred to as our “internal dialogue.” It’s also important for forming memories and making decisions.

How Does Psilocybin Affect The DMN?

Recent research has found that psilocybin can significantly alter activity in the Default Mode Network (DMN), offering potential therapeutic benefits for a variety of conditions. In a study conducted at Imperial College London, researchers administered psilocybin to participants before having them complete cognitive tests. They found that those who had taken psilocybin showed improved performance on tasks related to creativity, problem-solving, and decision-making compared to those who had not taken it. This suggested that psilocybin could be useful for improving cognition and potentially even treating certain mental health conditions such as depression and anxiety.
In support of these findings, a subsequent study conducted by Johns Hopkins University School of Medicine uncovered similar results after they administered psilocybin to healthy volunteers. Participants were asked to complete a range of cognitive tasks designed to measure their memory, concentration, and attention span, before and after taking the drug. They found that those who took the psilocybin showed better performance across all three measures compared with their pre-ingestion baseline results.
Another recent study from the University of Zurich examined how different doses of psilocybin affect brain connectivity in people with depression. They used functional Magnetic Resonance Imaging (fMRI) scanning to monitor changes in brain activity associated with taking different doses of the drug. The researchers discovered that higher doses correlated with reduced connections between regions within the DMN, a key network involved in depression. Lower doses led to increased connectivity between regions outside the DMN. This suggests that taking different amounts of psilocybin could bring about varying effects on mood regulation and emotion processing depending on individual needs and current state of mental health.

The Effects Of Long-Term Use

The potential long term outcomes of augmenting the default mode network via use of psychedelics are numerous and varied. Perhaps most notably, research into this area suggests that regular and repeated use of psychedelics may result in improved cognitive functioning as well as higher levels of creativity. In particular, studies suggest that individuals who utilize psychedelics on a regular basis display improved attentional capacity, greater cognitive flexibility, increased working memory, enhanced insightfulness, and even improved mood regulation. Psychedelic-induced neuroplasticity has been linked to a variety of positive psychological changes including increased openness to experience, greater sense of well-being, and improved self-efficacy.
Moreover, recent studies have also suggested that long term use of psychedelics may confer protective effects against certain mental health disorders such as depression and anxiety. In particular, research has indicated that regular users possess elevated levels of serotonin receptor binding and fewer signs of depression than those without prior exposure to psychedelic substances. Similarly, individuals who regularly engage with psychedelics also show reduced rates of anxiety due to the drug’s ability to induce feelings of safety and security.
Additionally, scientists have theorized that sustained use may potentially lead to more lasting structural changes within the brain such as altered neuronal connections or increases in dendritic spine density. These changes could further reduce vulnerability to mental health issues over time.
Overall then it appears that the potential long term outcomes of augmenting the default mode network via use of psychedelics are highly promising; not only do they promise improvements in various aspects related to cognition but they also appear to confer neuroprotective benefits which could help ameliorate various mental health disorders over time. It must be noted, however, that much more research needs to be done in this area before any definitive conclusions can be drawn regarding these potential long term impacts.

Conclusion

The research between psilocybin and the Default Mode Network is providing strong evidence that psilocybin has a significant potential to be used as an effective treatment for mental health and neuroplasticity. The connectivity of the DMN to areas of the brain related to emotional processing, memory, and self-referential thought suggest that psilocybin could lead to more positive outcomes in areas mental health and neuroplasticity.
Additionally, studies have shown that psilocybin can decrease activity in the DMN, leading to potentially decreased symptoms of depression and anxiety. Many researchers are now beginning to look into how this form of treatment might be integrated into traditional psychotherapeutic approaches. With all these promising findings, it’s likely that more research will continue on this topic with even more promising outcomes related to mental health neuroplasticity.

dr_shawn

Patient focused integrative health care. Utilizing effective natural approaches designed to be used alone or to compliment conventional medical care.


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