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19/May/2023

Vitamin injections have gained a lot of popularity in recent years, especially among celebrities and influencers. From improving skin clarity to boosting energy levels, the promised benefits of vitamin infusions are endless. However, are these claims backed by science, or is it just clever marketing? In this blog post, we’ll take a closer look at the ingredients in these celebrity vitamin infusions, the actual benefits they provide, and separate hype from fact.

The Ingredients:

A typical celebrity vitamin infusion usually contains a mixture of vitamins, minerals, and sometimes amino acids. Popular ingredients include vitamin C, B-vitamins, calcium, selenium, zinc and magnesium. These vitamins and minerals play an important role in almost all biological processes but do they really need to be injected rather than obtained through diet?

The Benefits:

Many celebrities claim that vitamin injections help with everything from weight loss to anti-aging. Still, most of these alleged benefits are based on anecdotal evidence rather than any scientific findings.
Let’s take a look at some of the actual research behind intravenous vitamins and minerals in order to separate fact from fiction.

Myers Cocktail:

The Myers’ Cocktail is an intravenous (IV) treatment that consists of a combination of vitamins and minerals, including magnesium, calcium, vitamin C, and various B vitamins. It was developed by Dr. John Myers in the 1960s and has been used to address various health conditions such as fatigue, migraines, fibromyalgia, and others. While there is limited research on the Myers’ Cocktail, some studies have explored its potential benefits:
  1. A study by Gaby (2002) published in “Alternative Medicine Review” provided a review of the clinical experience with the Myers’ Cocktail. The author reported that the IV treatment had shown positive effects on various conditions, including acute asthma attacks, migraines, fatigue, fibromyalgia, and chronic sinusitis. However, it’s important to note that this review is based on clinical observations rather than randomized controlled trials.
  2. A randomized controlled trial by Ali et al. (2009) published in “Medical Science Monitor” investigated the effects of the Myers’ Cocktail on fibromyalgia patients. The study found that the participants who received the IV treatment experienced significant improvements in pain, tender points, and depression compared to the control group.
  3. In a pilot study by Zhang et al. (2012) published in “Global Advances in Health and Medicine,” the researchers studied the effects of the Myers’ Cocktail on patients with chronic fatigue syndrome. They reported improvements in fatigue levels, but the small sample size and lack of a control group limit the study’s conclusions.

High dose Vitamin C for Cancer?

Yes, there has been research exploring the potential benefits of high-dose intravenous vitamin C in cancer treatment. However, the results are mixed, and more research is needed to establish its effectiveness conclusively. Here are a few notable studies:
  1. A study by Ma et al. (2014) published in “Science Translational Medicine” found that high-dose intravenous vitamin C selectively killed colorectal cancer cells with specific genetic mutations. The authors suggested that vitamin C might be used as a targeted therapy in some cases.
  2. A study by Welsh et al. (2013) published in “Cancer Cell” reported that high-dose intravenous vitamin C enhanced the effects of chemotherapy in mouse models of pancreatic cancer. The authors concluded that vitamin C could be a potential adjuvant in pancreatic cancer treatment.
  3. A systematic review by Fritz et al. (2014) published in “Canadian Medical Association Journal” analyzed several clinical trials on the use of intravenous vitamin C in cancer patients. They found that intravenous vitamin C was safe and well-tolerated, but its effectiveness in improving survival and quality of life was inconclusive.
  4. A phase II clinical trial by Hoffer et al. (2015) published in “PLOS ONE” investigated the effects of intravenous vitamin C combined with chemotherapy and radiation therapy in patients with stage 3 or 4 non-small cell lung cancer. The study found no significant improvement in overall survival, progression-free survival, or tumor response with the addition of vitamin C.

Magnesium:

Several research studies have explored the potential benefits of intravenous magnesium infusion in various clinical settings. Here are a few notable articles:
  1. James et al. (2010) published a study in “The Lancet” that investigated the effects of intravenous magnesium sulfate on patients at risk for developing eclampsia. They found that magnesium sulfate significantly reduced the risk of eclampsia and maternal death in women with pre-eclampsia.
  2. Shiga et al. (2012) conducted a study published in the “Journal of the American College of Cardiology” that demonstrated the benefits of intravenous magnesium sulfate in reducing the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.
  3. In a meta-analysis by Fawcett et al. (1999) published in the “British Medical Journal,” the researchers found that intravenous magnesium infusion reduced the risk of death in patients with suspected acute myocardial infarction.
  4. A study by Cinar et al. (2011) published in “Anesthesiology” examined the effects of intravenous magnesium sulfate on postoperative pain management in patients undergoing total knee arthroplasty. The study found that magnesium infusion reduced postoperative opioid consumption and improved pain scores.
  5. Miller et al. (2010) published a study in “Headache” that investigated the effects of intravenous magnesium sulfate on acute migraines. They found that magnesium infusion provided rapid and sustained pain relief in patients with migraines who had low serum ionized magnesium levels.

Glutathione:

Glutathione is an antioxidant that plays a crucial role in cellular detoxification and maintaining overall health. Research on glutathione infusion is limited, but several studies have explored its potential benefits in various clinical settings. Here are a few notable articles:
  1. A study by Hauser et al. (2009) published in “Neurology” investigated the effects of intravenous glutathione on Parkinson’s disease symptoms. They found that glutathione infusion improved symptoms in Parkinson’s patients, but the study had a small sample size and lacked a control group.
  2. A pilot study by Kern et al. (2011) published in “Medical Science Monitor” evaluated the effects of intravenous glutathione infusion on children with autism. The study reported improvements in some behavioral measures of autism, but the small sample size and lack of a control group limit the conclusions that can be drawn.
  3. A study by Pizzorno et al. (2014) published in “Integrative Medicine” assessed the impact of intravenous glutathione on quality of life in patients with fibromyalgia. The authors reported significant improvements in pain, energy, and overall well-being, but the study was not randomized or controlled.
  4. In a study by Allen et al. (2017) published in “Redox Biology,” the researchers explored the effects of intravenous glutathione on cystic fibrosis patients. They found that glutathione infusion improved lung function and reduced inflammation, suggesting potential benefits for cystic fibrosis patients.
  5. A study by Naito et al. (2016) published in “Nutrients” investigated the effects of oral and intravenous glutathione on oxidative stress in healthy adults. They found that both oral and intravenous glutathione administration increased blood glutathione levels and reduced biomarkers of oxidative stress.

The Risks:

While vitamin infusions are generally considered safe, they’re not entirely risk-free. Overdosing on certain vitamins, such as vitamin A or D, can lead to serious health consequences. Furthermore, injecting vitamins can put a strain on your liver and kidneys, which is particularly concerning for people with pre-existing liver or kidney conditions.

The Alternatives:

Most of the time we can obtain the vitamins, minerals and antioxidants our body requires thorough a healthy diet. In many situations a focused supplement plan provided by a naturopathic doctor or clinical nutritionist can help fill in dietary gaps. Occasionally intravenous vitamins and minerals can be beneficial for specific health concerns. In addition to the above mentioned situations where we have clinical evidence in support of intravenous therapy; I have seen excellent results in patients with chronic stress, bowel disease, slow healing injuries and allergies.

Conclusion:

In conclusion, while celebrity vitamin infusions may seem like a quick and easy fix, the truth is that there are only a handful of specific concerns that benefit from IV therapy.
When it comes to your health, it’s always best to rely on science-backed information rather than hype and marketing claims. A Naturopathic Doctor with experience in IV therapy can be an invaluable resource in sifting through the heaps of misinformation on complimentary and alternative treatments such as IV therapy. Interested in making an appointment? Book a free 15min introductory consult with me today!

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13/Oct/2015

Title: Reduction in symptoms associated with Fibromyalgia at six weeks using Intravenous Vitamins and Minerals (Myers Cocktail).

Running Header: Myers Cocktail for Fibromyalgia

Author: Dr. Shawn Meirovici N.D.

Physio-Logic 96 Scarsedale Road, Toronto, Ontario, M3B 2R7

Disclaimer: Patient consent was obtained

Key words: Intravenous, Vitamins, Minerals, Fibromyalgia

Abstract: Fibromyalgia is a musculoskeletal disorder characterized by widespread pain commonly with one or more coexisting symptoms. Treatment often includes both non-pharmacological and pharmacological therapy. Pharmacological therapy includes the use of antidepressants and GABA derivatives with varying success rates and often with unpleasant side effects. Micronutrient infusion is a newer approach with the majority of use in the field of alternative medicine. To date one placebo controlled pilot study has examined its use in fibromyalgia patients noting statistically significant effects on pain and fatigue. The following is a case study using a similar “cocktail” as the one used in the placebo controlled trial, for 4 treatments using the modified visual analogue scale of the fibromyalgia impact questionnaire (mVASFIQ) as an endpoint measure. Significant reduction in all parameters of the mVASFIQ was noted at 6 weeks, suggesting that micronutrient infusion should be further investigated as a treatment approach for fibromyalgia.

 

Background: I have a special interest in the treatment of chronic pain. Operating out of a rehabilitation clinic in Toronto, Canada has allowed me the opportunity to work with neurological conditions and traumatic injuries of which chronic pain is often a prevalent symptom. Fibromyalgia is characterized by chronic widespread pain and often involves disruption of many body systems including the gastrointestinal tract. While pharmaceutical intervention is focused on regulating the body’s response to pain, many alternative therapies are focused on restoring function to debilitated body systems. One such treatment is the Myers Cocktail: a intravenous micronutrient therapy that delivers vitamins and minerals directly into the blood stream thereby  bypassing the gastrointestinal tract. There is both a review and placebo controlled pilot study demonstrating intravenous micronutrient therapy as an effective treatment for symptom reduction in fibromyalgia. [1] [2]

 

Introduction: Fibromyalgia is characterized by chronic widespread pain, increased tenderness at specific sites known as “tender points,” un-refreshing sleep, fatigue and cognitive dysfunction not attributable to other disease states. While the etiology of fibromyalgia is not entirely clear, associations with trauma, adverse life events, impaired mood, anxiety, irritable bowel syndrome, cold intolerance, paresthesias and other medical conditions have been described. The pharmacologic treatment of fibromyalgia ranges from antidepressants to analgesics. Here we are commenting on a novel treatment involving the infusion of vitamins and minerals also known as a Myers Cocktail.

 

Case Presentation: J.M. is a 38-year old female who had been diagnosed with fibromyalgia in 2008. Her  symptoms started approximately 10 years ago after enduring a series of traumatic life events. Symptoms included: chronic widespread pain, non-restorative sleep, muscle weakness, morning stiffness, subjective swelling, multiple chemical sensitivities, frequent severe headaches, vestibular dysfunction, TMJ, paresthesia, chronic fatigue, dysmenorrhea, anxiety and irritable bowel syndrome. J.M. had tried a number of GABA derivatives, antidepressants and analgesics with varying degrees of relief but with significant adverse reactions including aphasia, depression and dyspepsia. At initial presentation, J.M. was taking Wellbutrin 300mg XL daily and Tylenol with Codeine as needed. She felt that she was starting to develop a tolerance to Wellbutrin. She was not taking any dietary supplements and was not on any type of specialized diet or exercise program.

J.M. was prescribed an intravenous infusion Myers Cocktail (B-complex 1ml, Dexpanthenol 250mg, Pyridoxine 100mg, Hydroxocobalamin 1mg, Ascorbic Acid 2000mg, Calcium Chlroide 100mg, Magnesium Chloride 1000mg and Sterile Water 46ml) via 60cc syringe with a 24 Gauge butterfly needle at the right median cubital vein, delivered over 15 minutes once per week for 4 infusion sessions. This patient completed a modified visual analogue scale of the fibromyalgia impact questionnaire (mVASFIQ) at initial consult (Image 1) and again after her final infusion (Image 2). She was also prescribed magnesium malate 1.5 grams per day, 1000iu vitamin D per day and 1mg melatonin at night 30 minutes before sleep. However, J.M. was admittedly not taking these supplements consistently during the 4 weeks of intravenous treatment.

The mVASFIQ score at treatment initiation was: (Fatigue 9.5, Insomnia 9.5, Depression 4.5, Anxiety 6.5, Rigidity 8.5, Pain 8.5, Difficulty with work 8.5) at four weeks the mVASFIQ score was: (Fatigue 3, Insomnia 5, Depression 1, Anxiety 3, Rigidity 3, Pain 3, Difficulty with work 3). Besides mild nausea and flushing during the first treatment no adverse effects were reported.

 

Discussion: Micronutrient infusion delivers vitamins and minerals involved in stress response, muscle contraction and nerve signaling, while able to bypass the need for gastrointestinal absorption. This is an effective delivery method for chronic conditions, such as fibromyalgia, where there is often gastrointestinal disruption as well as the potential for micronutrient deficiencies. The results of this case study demonstrate that micronutrient infusion Myers Cocktail may be an effective treatment for fibromyalgia related symptoms as indicated by a  decreased in symptoms score on mVASFIQ at 6 weeks post treatment. This joins the small collection of evidence for the validity of this treatment for fibromyalgia. More study into this treatment for fibromyalgia is warranted.

 

Confounding Factors: As was outlined in the treatment plan, J.M. received a few dietary supplements on initial consult; however, J.M. admitted to not taking these consistently throughout the 4 intravenous treatments. The patient received all 4 infusions by myself and was not blinded to the treatment. There was also no placebo control. Additionally, the patient may have been influenced by the doctor patient relationship or through placebo effect. However the significant improvement observed within a relatively short time helps to validate the results of this study.

[1] Intravenous Micronutrient Therapy (Myers’ Cocktail) for Fibromyalgia: A Placebo-Controlled Pilot Study, Ather et al., The Journal of Alternative and Complementary Medicine, Volume 15, Number 3, 2009, pp. 247-257

[2] Myers’ Cocktail, Dr. Alan Gaby M.D., Alternative Medicine Review, Volume 7, Number 5, 2002.

 Image 1

Table 1

mVASFIQ for J.M. on July 18th 2015 (patient incorrectly marked X in box rather than a check through the appropriate line, therefore, results have +/- 0.5 confidence interval.

Image 2

Table 2

mVASFIQ for J.M August 28th 2015.


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Patient focused integrative health care. Utilizing effective natural approaches designed to be used alone or to compliment conventional medical care.


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